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The information management system is an important part of the large modular manned spacecraft. According to the characteristics of the platform, astronaut and experiment data managed by the information management system, this paper puts forward the top-level framework of "Three networks + TT&C". At the same time, combined with the characteristics of multi-cabin combination, the information management system architecture oriented to the combination is designed. The main functions of the platform network, communication network and experiment network are designed, respectively. Finally, the functional subsystems of the TT&C system are summarized.